There_________any milk in this bottle. Could you give me another one?

A.is B.are C.isn't D.aren't

C

句意：这个瓶子里没有牛奶了，你能给我另一个吗？

is用于单三和不可数名词，are用于第二人称和复数；主语milk不可数名词，排除B/D；根据Could you give me another one?可知这瓶没有了；故选C。